Sick is a satirical magazine based largely on the hugely popular MAD Magazine. A large factor in making it so successful was the variety of contributors, which included contributors to the MAD Magazine.

Huckleberry Fink is the mascot of the magazine and is thought to resemble MAD mascot Alfred E. Neuman, while tagline Why Try Harder? has been likened to MAD's What, me worry? The magazine was started by Joe Simon, the creator of comic superhero Captain America.