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Combinatorial chemistry (combinational chemistry or сombichem) - Is used to synthesize large number of chemical compounds by combining sets of building blocks. Each newly synthesized compound's composition is slightly different from the previous one. A traditional chemist can synthesize 100-200 compounds per year. A combinatorial robotic system can produce in a year thousands or millions compounds which can be tested for potential drug candidates in a high-throughput screening process.
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Form of parallel synthesis in which the reaction vessels are maintained in a specified spatial distribution, e.g. the wells of a 96-well plate or pins held in a rack. Assay: An assay is a reproducible procedure for testing a particular reaction. In the drug discovery process, assays must be developed in order that candidate drugs can be screened for their effect on the drug target.
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One of a number of interchangeable reagents which can be used in combinatorial library synthesis, part of the structure of which becomes incorporated into the final product, i.e. its residue.
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Strategy for assembly of a combinatorial library. The solid support is divided into portions, each of which is subjected to reaction with a single building block. Pooling of these portions results in a single batch of solid support bearing a mixture of components. Repetition of the divide, couple, recombine processes results in a library where each discrete particle of solid support carries a single library member, and the number of members is equal to the product of the number of building blocks incorporated at each step (i.e. fully combinatorial).
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